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BIOCHEMISTRY, GENETICS & MOLECULAR BIOLOGY / REVIEW
Genetic polymorphism and current biotechnology approaches of therapeutic aspects within endometrial tumors
1
Faculty of Natural Sciences and Health Care, Batumi Shota Rustaveli State University, Georgia
2
Department of Bioinformatics, Pondicherry University, Chinna Kalapet, India
3
Laboratory for radiobiology and molecular genetics“VINČA“ Institute of Nuclear Sciences-National Institute of the Republic of Serbia,, University of Belgrade, Serbia
4
Department for experimental oncology, Institute for oncology and Radiology of Serbia, Serbia
5
Department of Basic Sciences, Faculty of Dental Medicine, Western Balkans University, Albania
Submission date: 2024-10-13
Acceptance date: 2025-01-16
Online publication date: 2025-02-24
Corresponding author
Irina Nakashidze
Faculty of Natural Sciences and Health Care, Batumi Shota Rustaveli State University, Georgia
Faculty of Natural Sciences and Health Care, Batumi Shota Rustaveli State University, Georgia
HIGHLIGHTS
- Gynecological tumors are important to women's health throughout the world.
- This review focuses on the advances in biotechnology that have contributed to the management of gyneco-logical tumors.
- Recent advances in biosensing technologies have significantly enhanced the detection of gynecological tumor markers.
KEYWORDS
TOPICS
ABSTRACT
Among oncological diseases of women, gynecological diseases deserve special attention. Gynecological tumors are important to women's health throughout the world. Notably, gynecologic malignancies represent a prevalent category of cancers affecting women globally. Single nucleotide polymorphisms have emerged as a promising source of genetic information to better understand complex diseases such as cancer, in terms of etiology, interindividual differences and treatment response. In this review, we summarize some selected gene single nucleotide polymorphisms’ implication in gynecological cancer susceptibility/predisposition, as well as the potential to use such genetic markers for improved diagnosis and individualized treatment of gynecological cancers. Furthermore, this review explores the advances in biotechnology that have contributed to the management of gynecological tumors, in particular endometrial tumors, with a focus on molecular diagnostics, therapeutic innovations, and personalized medicine. It is critical to investigate the single nucleotide gene polymorphisms as sociated with gynecologic cancer susceptibility/predisposition as some of them might be utilized as useful molecular markers for assessing gynecologic cancer predisposition and might be further used for diagnosis and treatment modalities in individuals with similar single nucleotide polymorphism profile. Moreover, recent advancements in biosensing technologies, particularly nano-biosensors and microfluidic biosensors, have significantly enhanced the detection of gynecological tumor markers. Taken together, the revolution in cancer research, diagnosis, and treatment has been made possible by advances in biotechnology in recent decades.
ABBREVIATIONS
APC: Adenomatous Polyposis Coli; BAX: BCL-2 Associated X protein; CIMP: CpG Island Methylator Phenotype; CHFR: Checkpoint with Forkhead-Associated and Ring Finger Domains; CASP8: Caspase 8; CD1: Cluster of Differentiation 1; COMT: Catechol-O-Methyltransferase; CIN: Cervical Intraepithelial Neoplasia; DACH1: Dachshund family transcription factor; GPR54: G Protein-Coupled Receptor 54; MLH1: MutL Homolog 1; HPSE: Heparanase; HOXA11: Homeobox A 11; IGF2R: Insulin like Growth Factor 2 Receptor; EC: Endometrial Cancer; ER: Estrogen Receptors; HPV: Human Papilloma Virus; MMR: Mismatch Repair; MSI: Micro-satellite Instability; PTEN: Phosphatase and tension homolog deleted on chromosome 10; P73: Tumor Protein P73; RASSF1A: Ras Association Domain Family Member 1A; RSK4: Ribosomal S6 Kinase 4; SNP: Single Nucleotide Polymorphism;
SPRY2: Sprouty Homolog 2; TGFBR2: Transforming Growth Factor Beta Receptor 2
ACKNOWLEDGEMENTS
None.
FUNDING
None.
CONFLICT OF INTEREST
The authors declare no conflict of interest.
PEER REVIEW INFORMATION
Article has been screened for originality
Externally peer reviewed.
REFERENCES (121)
1.
Abena, T. (2023). Biosensors Technological Advancement and Their Biomedical, Agricultural, Environmental and Food Industrial Applications: A Review. International Journal on Food, Agriculture and Natural Resources, 4(3), 46–57. https://doi.org/10.46676/ij-fa....
2.
Ahmed, H. G., Bensumaidea, S. H., Alshammari, F. D., Alenazi, F. S. H., ALmutlaq, B. A., Alturkstani, M. Z., & Aladani, I. A. (2017). Prevalence of Human Papillomavirus subtypes 16 and 18 among Yemeni Patients with Cervical Cancer. Asian Pacific Journal of Cancer Prevention, 18(6), 1543-1547. https://doi.org/10.22034/APJCP....
3.
Arafa, M., Somja, J., Dehan, P., Kridelka, F., Goffin, F., Boniver, J., & Delvenne, P. (2010). Current concepts in the pathology and epigenetics of endometrial carcinoma. Pathology, 42(7), 613–617. https://doi.org/10.3109/003130....
4.
Arciuolo, D., Travaglino, A., Raffone, A., Raimondo, D., Santoro, A., Russo, D., Varricchio, S., Casadio, P., Inzani, F., Seracchioli, R., Mollo, A., Mascolo, M., & Zannoni, G. F. (2022). TCGA molecular prognostic groups of endometrial carcinoma: current knowledge and future perspectives. International Journal of molecular Sciences, 23(19), 11684. https://doi.org/10.3390/ijms23....
5.
Arora, T., Mullangi, S., & Lekkala, M. R. (2023). Ovarian Cancer. In StatPearls. StatPearls Publishing. http://www.ncbi.nlm.nih.gov/bo....
6.
Baker-Rand, H., & Kitson, S. J. (2024). Recent advances in endometrial cancer prevention, early diagnosis and treatment. Cancers, 16(5), 1028. https://www.mdpi.com/2072-6694....
7.
Banno, K., Yanokura, M., Iida, M., Masuda, K., & Aoki, D. (2014). Carcinogenic mechanisms of endometrial cancer: Involvement of genetics and epigenetics. The journal of obstetrics and gynaecology research, 40(8), 1957–1967. https://doi.org/10.1111/jog.12....
8.
Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., & Jemal, A. (2018). Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A cancer journal for clinicians, 68(6), 394–424. https://doi.org/10.3322/caac.2....
9.
Cai, J., Cui, K., Niu, F., Jin, T., Huang, S., Zhang, Y., & Bao, S. (2019). Genetics of IL6 polymorphisms: Case-control study of the risk of endometrial cancer. Molecular genetics & genomic medicine, 7(4), e00600. https://doi.org/10.1002/mgg3.6....
10.
Cao, H., Yang, S., Yu, X., & Xi, M. (2020). Correlation between heparanase gene polymorphism and susceptibility to endometrial cancer. Molecular genetics & genomic medicine, 8(10), e1257. https://doi.org/10.1002/mgg3.1....
11.
Castellanos-Rubio, A., & Ghosh, S. (2019). Disease-Associated SNPs in Inflammation-Related lncRNAs. Frontiers in immunology, 10. https://doi.org/10.3389/fimmu.....
13.
Cheng, Y., Yang, L., Shi, G., Chen, P., Li, L., Fang, H., & Chen, C. (2021). Ninjurin 2 rs118050317 gene polymorphism and endometrial cancer risk. Cancer cell international, 21, 1-7. https://doi.org/10.1186/s12935....
14.
Das, A. P., Chopra, M., & Agarwal, S. M. (2022). Prioritization and Meta-analysis of regulatory SNPs identified IL6, TGFB1, TLR9 and MMP7 as significantly associated with cervical cancer. Cytokine, 157, 155954. https://doi.org/10.1016/j.cyto....
15.
Datkhile, K. D., Durgawale, P. P., Gudur, R. A., Gudur, A. K., & Patil, S. R. (2022). CYP2D6 and CYP2E1 Gene Polymorphisms and their Association with Cervical Cancer Susceptibility: A Hospital Based Case-Control Study from South-Western Maharashtra. Asian pacific journal of cancer prevention : APJCP, 23(8), 2591–2597. https://doi.org/10.31557/APJCP....
16.
Deli, T., Orosz, M., & Jakab, A. (2020). Hormone replacement therapy in cancer survivors–review of the literature. Pathology & oncology research, 26(1), 63-78. https://doi.org/10.1007/s12253....
17.
Deng, Y., Zhang, Y., Zhou, M., Wu, B., & Zhou, J. (2023). Application of Biosensors in Detecting Breast Cancer Metastasis. Sensors, 23(21), 8813. https://doi.org/10.3390/s23218....
18.
Dindere, M. E., Tanca, A., Rusu, M., Liehn, E. A., & Bucur, O. (2022). Intraoperative Tumor Detection Using Pafolacianine. International journal of molecular sciences, 23(21), 1–16. https://doi.org/10.3390/ijms23....
19.
Endometrial Cancer Prevention (PDQ®)—NCI (nciglobal,ncienterprise). (2023, October 15). [pdqCancerInfoSummary]. https://www.cancer.gov/types/u....
20.
Fan, X., Zou, X., Liu, C., Cheng, W., Zhang, S., Geng, X., & Zhu, W. (2021). MicroRNA expression profile in serum reveals novel diagnostic biomarkers for endometrial cancer. Bioscience reports, 41(6), SR20210111. https://doi.org/10.1042/BSR202....
21.
Felix, A. S., Weissfeld, J. L., Stone, R. A., Bowser, R., Chivukula, M., Edwards, R. P., & Linkov, F. (2010). Factors associated with Type I and Type II endometrial cancer. Cancer causes & control : CCC, 21(11), 1851–1856. https://doi.org/10.1007/s10552....
22.
Feng, Y., Wang, Z., Zhu, M., Li, S., Dong, S., Gong, L., Li, X., Zhang, S., Jia, T., Kong, X., Tian, J., & Sun, L. (2022). Single Nucleotide Polymorphisms of EXOC1, BCL2, CCAT2, and CARD8 Genes and Susceptibility to Cervical Cancer in the Northern Chinese Han Population. Frontiers in oncology, 12, 878529. https://doi.org/10.3389/fonc.2....
23.
Fernandes, A., Viveros-Carreño, D., Hoegl, J., Ávila, M., & Pareja, R. (2022). Human papillomavirus independent cervical cancer. International journal of gynecologic cancer, 32(1). https://doi.org/10.1136/ijgc-2....
24.
Galant, N., Krawczyk, P., Monist, M., Obara, A., Gajek, Ł., Grenda, A., Nicoś, M., Kalinka, E., & Milanowski, J. (2024). Molecular Classification of Endometrial Cancer and Its Impact on Therapy Selection. International journal of molecular sciences, 25(11), 5893. https://doi.org/10.3390/ijms25....
25.
Gebert, M., Jaśkiewicz, M., Moszyńska, A., Collawn, J. F., & Bartoszewski, R. (2020). The effects of single nucleotide polymorphisms in cancer RNAi therapies. Cancers, 12(11), 3119. https://doi.org/10.3390/cancer....
26.
Goldberg, A. D., Allis, C. D., & Bernstein, E. (2007). Epigenetics: A landscape takes shape. Cell, 128(4), 635–638. https://doi.org/10.1016/j.cell....
27.
Gu, X., Shen, H., Bai, W., Xiang, Z., Li, X., Zhang, R., Shi, F., Li, H., Zhu, G., & Guo, S. (2022). Endometrial cancer prognosis prediction using correlation models based on CDK family genes. Frontiers in genetics, 13, 1021600. https://doi.org/10.3389/fgene.....
28.
Guduri, M., Kolluru, S., Pasupulati, H., & Satyanarayana, P. (2024). A Comprehensive Review on PARP Inhibitors in Targeted Therapy for Cancers. Journal of international research in medical and pharmaceutical sciences, 19(2), 44–59. https://doi.org/10.56557/jirme....
29.
Helwa, R., Gansmo, L. B., Bjørnslett, M., Halle, M. K., Werner, H. M. J., Romundstad, P., Hveem, K., Vatten, L., Dørum, A., Lønning, P. E., & Knappskog, S. (2021). Impact of MDM2 promoter SNP55 (rs2870820) on risk of endometrial and ovarian cancer. Biomarkers: biochemical indicators of exposure, response, and susceptibility to chemicals, 26(4), 302–308. https://doi.org/10.1080/135475....
30.
Hewavisenti, R. V., Arena, J., Ahlenstiel, C. L., & Sasson, S. C. (2023). Human papillomavirus in the setting of immunodeficiency: Pathogenesis and the emergence of next-generation therapies to reduce the high associated cancer risk. Frontiers in immunology, 14. https://doi.org/10.3389/fimmu.....
31.
Ho, H. Y., Chung, K. S., Kan, C. M., & Wong, S. C. (2024). Liquid Biopsy in the Clinical Management of Cancers. International journal of molecular sciences, 25(16). https://doi.org/10.3390/ijms25....
32.
Hirschl, N., Leveque, W., Granitto, J., Sammarco, V., Fontillas, M., & Penson, R. T. (2024). PARP Inhibitors: Strategic Use and Optimal Management in Ovarian Cancer. Cancers, 16(5). https://doi.org/10.3390/cancer....
33.
Hitchins, M. P., Alvarez, R., Zhou, L., Aguirre, F., Dámaso, E., Pineda, M., Capella, G., Wong, J.J.L., Yuan, X., Ryan, S.R., Sathe, D.S., Baxter, M.D., Cannon, T., Biswas, R., DeMarco, T., Grzelak, D., Hampel, H., & Pearlman, R. (2023). MLH1-methylated endometrial cancer under 60 years of age as the “sentinel” cancer in female carriers of high-risk constitutional MLH1 epimutation. Gynecologic oncology, 171, 129-140. https://doi.org/10.1016/j.ygyn....
34.
Hu, J., Xu, Z., Ye, Z., Li, J., Hao, Z., & Wang, Y. (2023). The association between single nucleotide polymorphisms and ovarian cancer risk: A systematic review and network meta-analysis. Cancer medicine, 12(1), 541–556. https://doi.org/10.1002/cam4.4....
35.
Hrytsay, I., Mazur, Y., Ferneza, S., Sulaieva, O., & Volodko, N. (2024). Implementation of Molecular Profiling in the Diagnosis and Treatment Planning of Patients With Advanced Ovarian Cancer. Proceedings of the shevchenko scientific society. Medical sciences, 73(1). https://doi.org/10.25040/ntsh2....
36.
Hung, W.-C., Wu, T.-F., Ng, S.-C., Lee, Y., Shen, H.-P., Yang, S.-F., & Wang, P.-H. (2019). Involvement of endothelial nitric oxide synthase gene variants in the aggressiveness of uterine cervical cancer. Journal of cancer, 10(12), 2594–2600. https://doi.org/10.7150/jca.33....
37.
Ignatov, A., & Ortmann, O. (2020). Endocrine Risk Factors of Endometrial Cancer: Polycystic Ovary Syndrome, Oral Contraceptives, Infertility, Tamoxifen. Cancers, 12(7), 1766. https://doi.org/10.3390/cancer....
38.
Isbilen, E., Ulusal, H., Karaer, K., Kul, S., Yaman, D. M., Tepe, N. B., Kanbur, H. C., Tarakcioglu, M., & Ozyurt, A. B. (2020). VDR gene polymorphisms as a significant factor in unexplained infertility. Gene reports, 21, 100962. https://doi.org/10.1016/j.genr....
39.
Kanaya, T., Kyo, S., Sakaguchi, J., Maida, Y., Nakamura, M., Takakura, M., Hashimoto, M., Mizumoto, Y., & Inoue, M. (2005). Association of mismatch repair deficiency with PTEN frameshift mutations in endometrial cancers and the precursors in a Japanese population. American journal of clinical pathology, 124(1), 89–96. https://doi.org/10.1309/PAACLG....
40.
Katagiri, R., Iwasaki, M., Abe, S. K., Islam, M. R., Rahman, M. S., Saito, E., Merritt, M.A., Choi, J.Y., Shin, A., Sawada, N., Tamakoshi, A., Koh, W.P., Sakata, R., Tsuji, I., Kim, J., Nagata, C., Park, S.K., Kweon, S.S., Shu, X.O., Gao, Y.T., Tsugane, S., Kimura, T., Yuan, J.M., Kanemura, S., Lu, Y., Sugawara, Y., Wada, K., Shin, M.H., Ahsan, H., Boffetta, P., Chia, K.S., Matsuo, K., Qiao, Y.L., Rothman, N., Zheng, W., Inoue, M., & Kang, D. (2023). Reproductive factors and endometrial cancer risk among women. JAMA network open, 6(9), e2332296-e2332296. https://doi.org/10.1001/jamane....
41.
Kaur Jawanda, I., Soni, T., Kumari, S., & Prabha, V. (2024). Deciphering the potential of proteomic based biomarkers in women’s reproductive diseases: Empowering precision medicine in gynecology. Biomarkers, 29(1), 7–17. https://doi.org/10.1080/135475....
42.
Keyvani, V., Mollazadeh, S., Riahi, E., Alsadat, R. M., Anvari, K., & Avan, A. (2024). Nanotechnological Advances in the Diagnosis of Gynecological Cancers and Nanotheranostics. Current pharmaceutical design, 30(33), 2619–2630. https://doi.org/10.2174/011381....
43.
Khatami, F., Shahriari, S., Aminimoghaddam, S., Klashami, Z. N., Farahani, M. S., Teimoori-Toolabi, L., Amoli, M.A., Asadi, M., & Rashidi, B. H. (2023). PTEN promoter methylation and expression in endometrial cancer tissues. Epigenomics, 15(8), 507-516. https://doi.org/10.2217/epi-20....
44.
Kiani, P., Vatankhahan, H., Zare-Hoseinabadi, A., Ferdosi, F., Ehtiati, S., Heidari, P., Dorostgou, Z., Movahedpour, Baktash, A., Rajabivahid, M., & Khatami, S. H. (2024). Electrochemical biosensors for early detection of breast cancer. Clinica chimica acta, 119923. https://doi.org/10.1016/j.cca.....
45.
Kokilavani, R., Kotal, H., Kaushik, A., & Jana, Saikat K. (2024). Nanotechnology-Assisted Electrochemical Immunosensors for Human Reproductive Cancer Diagnostics: Toward Laboratory to Clinics to Personalized Health Care. Journal of the electrochemical society, 171(5), 057516. https://doi.org/10.1149/1945-7....
46.
Kokemüller, L., Ramachandran, D., Schürmann, P., Geffers, R., Jentschke, M., Böhmer, G., Strauß, H.G., Hirchenhain, C., Schmidmayr, M., Müller, F., Fasching, P.A., Luyten, A., Häfner, N., Hillemanns, P., & Dörk, T. (2025). Germline variants of homology-directed repair or mismatch repair genes in cervical cancer. International journal of cancer. https://doi.org/10.1002/ijc.35....
47.
Koo, K. H., Jeong, W. J., Cho, Y. H., Park, J. C., & Choi, K. Y. (2015). K-Ras stabilization by estrogen via PKCδ is involved in endometrial tumorigenesis. Oncotarget, 6(25), 21328. https://doi.org/10.18632/oncot....
48.
Kotrikadze, N., Tufinashvili, T., Nakashidze, I., Ramishvili, L., Alibegashvili, M., Gordeziani, M., Sepiashvilli, B., & Ahmad, S. (2019a). Morpho-structural Peculiarities of Blood Formed Elements and Clinic-pathological Characteristics in Women with Uterine (Benign, Malignant) Tumors in Menopausal Age. The FASEB journal, 33(S1). https://doi.org/10.1096/fasebj....
49.
Kotrikadze, N., Tufinashvili, T., Ramishvili, L., Alibegashvili, M., Nakashidze, I., Gordeziani, M., Sepiashvilli, B., & Ahmad, S. (2019b). The study of the antioxidant enzymes, the activity of acid phosphatase and alteration of lipid peroxidation in women with uterine tumors. E-Poster Viewings, A108.3-A109. https://doi.org/10.1136/ijgc-2....
50.
Kotrikadze, N., Tupinashvili, T., Ramishvili, L., Alibegashvili, M., Nakashidze, I., Nemsadze, G., Gordeziani, M., Khazaradze, A., Sepiashvilli, B., & Ahmad, S. (2019c). Differential assessments of blood lipids, lipid peroxidation, antioxidant status, and fatty acids in women with uterine tumors during menopausal period. Gynecologic oncology, 154, 99–100. https://doi.org/10.1016/j.ygyn....
51.
Kotrikadze, N., Alibegashvili, M., Ramishvili, L., Nakashidze, I., Tevdoradze, T., Gordeziani, M., Zibzibadze, M., Khazaradze, A., Sepiashvilli, B., & Ahmad, S. (2020). Thermodynamic parameters of blood plasma proteins in women with breast tumors. Gynecologic oncology, 159, 357. https://doi.org/10.1016/j.ygyn....
52.
Kovarova, A., Kastrati, G., Pekarkova, J., Metelka, R., Drbohlavova, J., Bilkova, Z., Selesovska, R., & Korecka, L. (2023). Biosensor with electrochemically active nanocomposites for signal amplification and simultaneous detection of three ovarian cancer biomarkers. Electrochimica acta, 469, 143213. https://doi.org/10.1016/J.ELEC....
53.
Kumar, G.G., Paul, S. F. D., Molia, C., Manickavasagam, M., Ramya, R., Usha Rani, G., Ganesan, N., & Andrea Mary, F. (2022). The association between CYP17A1, CYP19A1, and HSD17B1 gene polymorphisms of estrogen synthesis pathway and ovarian cancer predisposition. Meta gene, 31, 100985. https://doi.org/10.1016/j.mgen....
54.
Kumar, V. R., Kampan, N. C., Abd Aziz, N. H., Teik, C. K., Shafiee, M. N., & Menon, P. S. (2023). Recent Advances in Surface Plasmon Resonance (SPR) Technology for Detecting Ovarian Cancer Biomarkers. Cancers, 15(23), 1–26. https://doi.org/10.3390/cancer....
55.
Kuntamung, K., Sangthong, P., Jakmunee, J., & Ounnunkad, K. (2024). Simultaneous immunodetection of multiple cervical cancer biomarkers based on a signal-amplifying redox probes/polyethyleneimine-coated gold nanoparticles/2D tungsten disulfide/graphene oxide nanocomposite platform. Bioelectrochemistry, 160, 108780. https://doi.org/10.1016/J.BIOE....
56.
Leitão, S. T., Rubiales, D., & Vaz Patto, M. C. (2023). Identification of novel sources of partial and incomplete hypersensitive resistance to rust and associated genomic regions in common bean. BMC plant biology, 23(1), 610. https://doi.org/10.1186/s12870....
57.
Li, D., Liu, Y., Kong, D., Papukashvili, D., Rcheulishvili, N., Zhao, H., Li, Y., Hou, C., Ma, J., Lu, X., & Bai, W. (2022). Vitamin D Receptor Gene Polymorphisms and the Risk of CIN2+ in Shanxi Population. BioMed research international, 2022, 1–9. https://doi.org/10.1155/2022/6....
58.
Lim, D., & Oliva, E. (2010). Nonendometrioid endometrial carcinomas. Seminars in diagnostic pathology, 27(4), 241–260. https://doi.org/10.1053/j.semd....
59.
Liu, G.-C., Zhou, Y.-F., Su, X.-C., & Zhang, J. (2019). Interaction between TP53 and XRCC1 increases susceptibility to cervical cancer development: A case control study. BMC cancer, 19(1), 24. https://doi.org/10.1186/s12885....
60.
Liu, H., Sun, L., Liu, X., Wang, R., & Luo, Q. (2023a). Associations between non-coding RNAs genetic polymorphisms with ovarian cancer risk: A systematic review and meta-analysis update with trial sequential analysis. Medicine, 102(39), e35257. https://doi.org/10.1097/MD.000....
61.
Liu, L., Habeshian, T. S., Zhang, J., Peeri, N. C., Du, M., De Vivo, I., & Setiawan, V. W. (2023b). Differential trends in rising endometrial cancer incidence by age, race, and ethnicity. JNCI cancer spectrum, 7(1), pkad001. https://doi.org/10.1093/jncics....
62.
Lm, D., Rj, W., Ua, A., Sd, S., & Cr, E. (2011). Trends in endometrial cancer incidence rates in the United States, 1999-2006. Journal of women’s health (2002), 20(8). https://doi.org/10.1089/jwh.20....
63.
Mahdy, H., Casey, M. J., & Crotzer, D. (2022). Endometrial Cancer. In StatPearls [Internet]. StatPearls.
65.
Makker, V., MacKay, H., Ray-Coquard, I., Levine, D. A., Westin, S. N., Aoki, D., & Oaknin, A. (2021). Endometrial cancer. Nature reviews disease primers, 7(1), 88. https://doi.org/10.1038/s41572....
66.
Malonek, D., Dekel, B. Z., Haran, G., Reens-Carmel, R., Groisman, G. M., Hallak, M., & Bruchim, I. (2020). Rapid intraoperative diagnosis of gynecological cancer by ATR-FTIR spectroscopy of fresh tissue biopsy. Journal of biophotonics, 13(9), 1–10. https://doi.org/10.1002/jbio.2....
67.
Marković, A., Grujičić, D., Živković Radojević, M., & Milošević-Djordjević, O. (2024). Measurement of chromosomal instability and level of DNA damage in peripheral blood mononuclear cells of endometrial cancer patients. Mutagenesis, 39(3), 172-180. https://doi.org/10.1093/mutage....
68.
McInerney, E. M., & Katzenellenbogen, B. S. (1996). Different regions in activation function-1 of the human estrogen receptor required for antiestrogen- and estradiol-dependent transcription activation. The journal of biological chemistry, 271(39), 24172–24178. https://doi.org/10.1074/jbc.27....
69.
Metzger, D., Ali, S., Bornert, J.-M., & Chambon, P. (1995). Characterization of the Amino-terminal Transcriptional Activation Function of the Human Estrogen Receptor in Animal and Yeast Cells. Journal of biological chemistry, 270(16), 9535–9542. https://doi.org/10.1074/jbc.27....
70.
Miyamoto, T., Shiozawa, T., Kashima, H., Feng, Y.-Z., Suzuki, A., Kurai, M., Nikaido, T., & Konishi, I. (2006). Estrogen up-regulates mismatch repair activity in normal and malignant endometrial glandular cells. Endocrinology, 147(10), 4863–4870. https://doi.org/10.1210/en.200....
71.
Momenimovahed, Z., Tiznobaik, A., Taheri, S., & Salehiniya, H. (2019). Ovarian cancer in the world: Epidemiology and risk factors. International journal of women’s health, 11, 287–299. https://doi.org/10.2147/IJWH.S....
72.
Moreno-Bueno, G., Rodríguez-Perales, S., Sánchez-Estévez, C., Hardisson, D., Sarrió, D., Prat, J., Cigudosa, J. C., Matias-Guiu, X., & Palacios, J. (2003). Cyclin D1 gene (CCND1) mutations in endometrial cancer. Oncogene, 22(38), 6115–6118. https://doi.org/10.1038/sj.onc....
73.
Nakashidze, I., & Ahmad, S. (2019). Genetic predisposition for pancreatic cancer. In Theranostic Approach for Pancreatic Cancer (pp. 153–169). Elsevier. https://doi.org/10.1016/B978-0....
74.
Nakashidze, I., Dariya, B., Peshkova, T., & Beridze, S. (2020). The Genetic Polymorphisms in Colon Cancer. Critical reviewsTM in oncogenesis, 25(4), 405–415. https://doi.org/10.1615/CritRe....
75.
Nakashidze, I., Diasamidze, A., Baratashvili, D., Nagervadze, M., Alibegashvili, M., Ramishvili, L., Gordeziani, M., Khazaradze, A., & Kotrikadze, N. (2014). Alteration of Sex and Non-Sex Hormones and Distribution Features of Blood ABO System Groups among the Women with Uterine Body Tumors. Journal of cancer therapy, 05(05), 411–419. https://doi.org/10.4236/jct.20....
76.
Nees, L. K., Heublein, S., Steinmacher, S., Juhasz-Böss, I., Brucker, S., Tempfer, C. B., & Wallwiener, M. (2022). Endometrial hyperplasia as a risk factor of endometrial cancer. Archives of gynecology and obstetrics, 1-15. https://doi.org/10.1007/s00404....
77.
Nujhat, S., Leese, H. S., Di Lorenzo, M., Bowen, R., & Moise, S. (2023). Advances in screening and diagnostic lab-on-chip tools for gynaecological cancers–a review. Artificial cells, nanomedicine and biotechnology, 51(1), 618–629. https://doi.org/10.1080/216914....
78.
Ouh, Y. T., Oh, Y., Joo, J., Woo, J. H., Han, H. J., Cho, H. W., Lee, J.K., Chun, Y., Lim, M.N., & Hong, J. H. (2024). Assessing the New 2020 ESGO/ESTRO/ESP Endometrial Cancer Risk Molecular Categorization System for Predicting Survival and Recurrence. Cancers, 16(5), 965. https://doi.org/10.3390/cancer....
79.
Ozgor, B. Y., Iyibozkurt, C., Bastu, E., Berkman, S., Yalcın, O., Cakmakoglu, B., & Saygılı, H. (2019). Investigation of resistin 420 and 62 gene polymorphism in patients with endometrial cancer. Taiwanese journal of obstetrics & gynecology, 58(1), 164–167. https://doi.org/10.1016/j.tjog....
80.
Park, J. E., Lee, T., Cho, E. H., Jang, M. A., Won, D., Park, B., Ki, C.S., & Kong, S. Y. (2024). Carrier Frequency and Incidence of MUTYH-Associated Polyposis Based on Database Analysis in East Asians and Koreans. Annals of laboratory medicine, 45(1), 77. https://doi.org/10.3343/alm.20....
81.
Parvez, A., Choudhary, F., Mudgal, P., Khan, R., Qureshi, K. A., Farooqi, H., & Aspatwar, A. (2023). PD-1 and PD-L1: Architects of immune symphony and immunotherapy breakthroughs in cancer treatment. Frontiers in immunology, 14, 1–16. https://doi.org/10.3389/fimmu.....
82.
Pandya, D., Tomita, S., Rhenals, M. P., Swierczek, S., Reid, K., Camacho-Vanegas, O., Camacho, C., Engelman, K., Polukort, S., RoseFigura, J., Chuang, L., Andikyan, V., Cohen, S., Fiedler, P., Sieber, S., Shih, I.M., Billaud, J.N., Sebra, R., Reva, B., Dottino, P., & Martignetti, J. A. (2024). Mutations in cancer-relevant genes are ubiquitous in histologically normal endometrial tissue. Gynecologic oncology, 185, 194-201. https://doi.org/10.1016/j.ygyn....
83.
Pati, S., Irfan, W., Jameel, A., Ahmed, S., & Shahid, R. K. (2023). Obesity and cancer: a current overview of epidemiology, pathogenesis, outcomes, and management. Cancers, 15(2), 485. https://doi.org/10.3390/cancer....
84.
Petrović, N., Nakashidze, I. & Nedeljković, M. Breast Cancer Response to Therapy: Can microRNAs Lead the Way?. J Mammary Gland Biol Neoplasia 26, 157–178 (2021). https://doi.org/10.1007/s10911....
85.
Petrovic, N., Sami, A., Martinovic, J., Zaric, M., Nakashidze, I., Lukic, S., & Jovanovic-Cupic, S. (2017). TIMP-3 mRNA expression levels positively correlates with levels of miR-21 in in situ BC and negatively in PR positive invasive BC. Pathology - research and practice, 213(10), 1264-1270. https://doi.org/10.1016/j.prp.....
86.
Pierre, M. D., Edy, M., Fletcher Prieto, M. D., Viviana, A., Hernández Blanquisett MD, A., Gómez Camacho, M. D., Medina, R.P., Silva, L.M., Fernández, R., & desarrollador del Consenso, G. (2024). Colombian consensus for the molecular diagnosis of endometrial cancer. Revista colombiana de obstetricia y ginecología, 75(1). https://doi.org/10.18597/rcog.....
87.
Prakash, A., Das Purkayastha, B. P., Srivastava, S., Chaturvedi, S., Ali, A., Aggarwal, D. D., & Roy, J. K. (2022). Novel Variant Identified in the Enhancer Region of Host Transcription Factor, BRN3A, is a Significant Risk Factor for HPV-Induced Uterine Cervix Cancer. International journal of molecular and cellular medicine, 11(2), 88–103. https://doi.org/10.22088/IJMCM....
88.
Priya, N. D., Kumar, K. V. N., Charani, M. S., Bindu, D., Reddy, K. L., & Gowthami, Y. (2024). Biomarker Panel for Early Detection in Uterine Cancer: A Review. Asia pacific journal of cancer biology, 9(2), 201–208. https://doi.org/10.31557/APJCB....
89.
Rahman, M. A., Hasan, M. M., Hossain, A., Alam, K. M., Sultana, R., Mazid, M. A., & Rahman, M. M. (2023). Analysis of E-cadherin (CDH1) Gene Polymorphism and Its Association with Cervical Cancer Risk in Bangladeshi Women. Asian pacific journal of cancer prevention: APJCP, 24(7), 2361–2368. https://doi.org/10.31557/APJCP....
90.
Rahmani, F., Hasanzadeh, M., Hassanian, S. M., Khazaei, M., Esmaily, H., Asef-Agah, S. A., Naghipour, A., A Ferns, G., & Avan, A. (2020). Association of a genetic variant in the angiopoietin like protein 4 gene with cervical cancer. Pathology, research and practice, 216(7), 153011. https://doi.org/10.1016/j.prp.....
91.
Rodriguez, A. C., Blanchard, Z., Maurer, K. A., & Gertz, J. (2019). Estrogen signaling in endometrial cancer: a key oncogenic pathway with several open questions. Hormones and cancer, 10, 51-63. https://doi.org/10.1007/s12672....
92.
Rockett, T. W., Almahyawi, M., Ghimire, M. L., Jonnalagadda, A., Tagliaferro, V., Seashols-Williams, S. J., Bertino, M. F., Caputo, G. A., & Reiner, J. E. (2024). Cluster-Enhanced Nanopore Sensing of Ovarian Cancer Marker Peptides in Urine. ACS sensors, 9(2), 860–869. https://doi.org/10.1021/acssen....
93.
Ruiz De La Cruz, M., De La Cruz Montoya, A. H., Rojas Jiménez, E. A., Martínez Gregorio, H., Díaz Velásquez, C. E., Paredes De La Vega, J., De La Cruz Hernández-Hernández, F., & Vaca Paniagua, F. (2021). Cis-Acting Factors Causing Secondary Epimutations: Impact on the Risk for Cancer and Other Diseases. Cancers, 13(19), 4807. https://doi.org/10.3390/cancer....
94.
Saegusa, M., Hashimura, M., Yoshida, T., & Okayasu, I. (2001). β-Catenin mutations and aberrant nuclear expression during endometrial tumorigenesis. British journal of cancer, 84(2), 209–217. https://doi.org/10.1054/bjoc.2....
95.
Sahin, S., & Yıldırım Tirgil, N. (2024). Circulating tumor DNA (ctDNA) Detection via electrochemical Biosensing Tools. MANAS journal of engineering, 12(1), 104–115. https://doi.org/10.51354/mjen.....
96.
Shahazi, R., Saddam, A. I., Islam, M. R., Rahman, M. M., Paimard, G., Kumer, A., Alam, Md. M., & Mahamud, Md. K. (2024). Recent progress in Nanomaterial based biosensors for the detection of cancer biomarkers in human fluids. Nano carbons, 2(2), 1254. https://doi.org/10.59400/n-c.v....
97.
Shaikh, A. P., Khurana, R., Shaikh, N. P., Barua, J. D., Ali, A., Murvanidze, I., Saralidze, E., & Nakashidze, I. (2023). Peculiarities of some candidate gene polymorphisms in Parkinson’s disease. Pomeranian journal of life sciences, 69(2), Article 2. https://doi.org/10.21164/pomjl....
98.
Shaikh, A. P., Shaikh, N. P., & Irina, N. (2022). VDR Gene SNPs in Gastrointestinal Tumors. JSM gastroenterology and hepatology. https://doi.org/10.47739/2373-....
99.
Shaikh, N. P., Murvanidze, I., Shaikh, A. P., Khurana, R., & Nakashidze, I. (2023). The Altered Gene Expression and Epigenetic Mechanisms in Breast Cancer. Journal of biomedical research & Environmental sciences, 4(10), 1461–1469. https://doi.org/10.37871/jbres....
100.
Sherman, M. E., Sturgeon, S., Brinton, L. A., Potischman, N., Kurman, R. J., Berman, M. L., Mortel, R., Twiggs, L. B., Barrett, R. J., & Wilbanks, G. D. (1997). Risk factors and hormone levels in patients with serous and endometrioid uterine carcinomas. Modern pathology: An official journal of the united states and canadian academy of pathology, Inc, 10(10), 963–968.
101.
Sofiyeva, N., Krakstad, C., Halle, M. K., O’Mara, T. A., Romundstad, P., Hveem, K., Vatten, L., Lønning, P. E., Gansmo, L. B., & Knappskog, S. (2023). APOBEC3A/B deletion polymorphism and endometrial cancer risk. Cancer medicine, 12(6), 6659–6667. https://doi.org/10.1002/cam4.5....
102.
Srinivasan, S., Clements, J. A., & Batra, J. (2016). Single nucleotide polymorphisms in clinics: Fantasy or reality for cancer?. Critical reviews in clinical laboratory sciences, 53(1), 29-39. https://doi.org/10.3109/104083....
103.
Vitamin D receptor gene polymorphisms and uterine fibroid incidence in Caucasian women. (n.d.). Retrieved December 8, 2023, from https://www.archivesofmedicals... receptor-gene-polymorphisms-and-uterine-fibroid-incidence-in-Caucasian,99548,0,2.html.
104.
Vegesna, Dr. V. (2024). AI-Driven Personalized Medicine: A Frame Work for Tailored Cancer Treatment. International journal of innovative research in advanced engineering, 11(06), 747-752. https://doi.org/10.26562/ijira....
105.
Wakkerman, F. C., Wu, J., Putter, H., Jürgenliemk-Schulz, I. M., Jobsen, J. J., Lutgens, L. C., Haverkort, M.A.D., de Jong, M.A., Mens, J.W.M., Wortman, B.G., Nout, R.A., Léon-Castillo, A., Powell, M.E., Mileshkin, L.R., Katsaros, D., Alfieri, J., Leary, A., Singh, N., de Boer, S.M., Nijman, H.W., Smit, V.T.H.B.M., Bosse, T., Koelzer, V.H., Creutzberg, C.L., & Horeweg, N. (2024). Prognostic impact and causality of age on oncological outcomes in women with endometrial cancer: a multimethod analysis of the randomised PORTEC-1, PORTEC-2, and PORTEC-3 trials. The lancet oncology, 25(6), 779-789. https://doi.org/10.1016/S1470-....
106.
Wang, S., Sun, H., Jia, Y., Tang, F., Zhou, H., Li, X., Zhou, J., Huang, K., Zhang, Q., Hu, T., Yang, R., Wang, C., Xi, L., Deng, D., Wang, H., Wang, S., Ma, D., & Li, S. (2015). Association of 42 SNPs with genetic risk for cervical cancer: An extensive meta-analysis. BMC medical genetics, 16(1), 25. https://doi.org/10.1186/s12881....
107.
Wang, H., Zhang, Y., Zhang, H., Cao, H., Mao, J., Chen, X., Wang, L., Zhang, N., Luo, P., Xue, J., Qi, X., Dong, X., Liu, G., & Cheng, Q. (2024). Liquid biopsy for human cancer: Cancer screening, monitoring, and treatment. MedComm, 5(6), 1–24. https://doi.org/10.1002/mco2.5....
108.
Wang, X., Wang, L., Lin, H., Zhu, Y., Huang, D., Lai, M., Xi, X., Huang, J., Zhang, W., & Zhong, T. (2024). Research progress of CTC, ctDNA, and EVs in cancer liquid biopsy. Frontiers in oncology, 14, 1–22. https://doi.org/10.3389/fonc.2....
109.
Wang, X., Glubb, D. M., & O’Mara, T. A. (2023). Dietary factors and endometrial cancer risk: a mendelian randomization study. Nutrients, 15(3), 603. https://doi.org/10.3390/nu1503....
110.
Weisenberger, D. J., Siegmund, K. D., Campan, M., Young, J., Long, T. I., Faasse, M. A., Kang, G. H., Widschwendter, M., Weener, D., Buchanan, D., Koh, H., Simms, L., Barker, M., Leggett, B., Levine, J., Kim, M., French, A. J., Thibodeau, S. N., Jass, J., Haile, R., & Laird, P. W. (2006). CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. Nature genetics, 38(7), 787–793. https://doi.org/10.1038/ng1834.
111.
Williams, L., Henry, C., Simcock, B., & Filoche, S. (2024). Increasing incidence of endometrial cancer in Aotearoa New Zealand: Health professionals’ perspective. Australian and new zealand journal of obstetrics and gynaecology, 64, 114-119. https://doi.org/10.1111/ajo.13....
112.
Wu, F., Gao, H., Qiu, R., Zhang, H., Ren, X., Qi, X., Miao, M., & Rui, C. (2024). A novel ratiometric electrochemical immunosensor for the detection of cancer antigen 125 based on three-dimensional carbon nanomaterial and MOFs. Microchemical journal, 200, 110372. https://doi.org/10.1016/J.MICR....
113.
Xiong, X. D., Luo, X. P., Cheng, J., Liu, X., Li, E. M., & Zeng, L. Q. (2014). A genetic variant in pre-miR 27a is associated with a reduced cervical cancer risk in southern Chinese women. Gynecologic oncology, 132(2), 450-454. https://doi.org/10.1016/j.ygyn....
114.
Xu, L., Qiu, Y., Feng, L., Zhou, L., Chen, X., & Yu, D. (2020). Correlation between single nucleotide polymorphisms of DACH1 gene microRNA binding site and susceptibility of patients with endometrial cancer. Medicine, 99(25), e20793. https://doi.org/10.1097/MD.000....
115.
Yang, H. P., Wentzensen, N., Trabert, B., Gierach, G. L., Felix, A. S., Gunter, M. J., Hollenbeck, A., Park, Y., Sherman, M. E., & Brinton, L. A. (2013). Endometrial Cancer Risk Factors by 2 Main Histologic Subtypes. American journal of epidemiology, 177(2), 142–151. https://doi.org/10.1093/aje/kw....
116.
Yi, T.-Z., Guo, J., Zhou, L., Chen, X., Mi, R.-R., Qu, Q.-X., Zheng, J.-H., & Zhai, L. (2011). Prognostic value of E-cadherin expression and CDH1 promoter methylation in patients with endometrial carcinoma. Cancer investigation, 29(1), 86–92. https://doi.org/10.3109/073579....
117.
Yang, Y., Wu, S. F., & Bao, W. (2024). Molecular subtypes of endometrial cancer: Implications for adjuvant treatment strategies. International journal of gynecology & obstetrics, 164(2), 436-459. https://doi.org/10.1002/ijgo.1....
118.
Zhang, Q.-Y., Yi, D.-Q., Zhou, L., Zhang, D.-H., & Zhou, T.-M. (2011). Status and significance of CpG island methylator phenotype in endometrial cancer. Gynecologic and obstetric investigation, 72(3), 183–191. https://doi.org/10.1159/000324....
119.
Zhang, C., Li, T., Zhao, Q., Ma, R., Hong, Z., Huang, X., Gao, P., Liu, J., Zhao, J., & Wang, Z. (2024). Advances and Prospects in Liquid Biopsy Techniques for Malignant Tumor Diagnosis and Surveillance. Small, 2404709(77). https://doi.org/10.1002/smll.2....
120.
Zhang, R., Y Siu, M. K., S Ngan, H. Y., & L Chan, K. K. (2022). Molecular Biomarkers for the Early Detection of Ovarian Cancer. International journal of molecular sciences, 23(19), 12041. https://doi.org/10.3390/ijms23....
121.
Zmarzły, N., Januszyk, S., Mieszczański, P., Morawiec, E., Buda, P., Dziobek, K., Opławski, M., & Boroń, D. (2023). Endothelin-3 is epigenetically silenced in endometrioid endometrial cancer. Journal of cancer research and clinical oncology, 149(9), 5687-5696. https://doi.org/10.1007/s00432....
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