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Application of salt-assisted liquid-liquid extraction in bioanalytical methods
1
Istanbul University, Faculty of Pharmacy, Department of Analytical Chemistry, Istanbul, Türkiye
Submission date: 2024-08-21
Final revision date: 2024-09-19
Acceptance date: 2024-09-30
Online publication date: 2024-10-15
Corresponding author
Selen Al
Istanbul University, Faculty of Pharmacy, Department of Analytical Chemistry, Istanbul, Türkiye
Istanbul University, Faculty of Pharmacy, Department of Analytical Chemistry, Istanbul, Türkiye
KEYWORDS
TOPICS
ABSTRACT
This review provides a comprehensive analysis of bioanalytical methods employed for the quantification of drug molecules in various biological matrices, including human plasma, urine, breast milk, and mouse plasma. The study not only examines traditional sample preparation techniques such as protein precipitation (PP), liquid-liquid extraction (LLE), and solid-phase extraction (SPE), but also delves into the relatively new and innovative salting-assisted liquid-liquid extraction (SALLE). It offers a thorough comparison of analytical methods utilizing SALLE, focusing on key parameters such as analysis time, calibration range, and the type and quantity of salts and organic solvents used. This review aims to serve as an essential resource for researchers and practitioners in selecting the most suitable bioanalytical methods for pharmacokinetic studies and drug monitoring, ultimately enhancing data quality and analytical efficiency in both clinical and research settings.
ACKNOWLEDGEMENTS
None.
FUNDING
None.
CONFLICT OF INTEREST
The authors declare no conflict of interest.
PEER REVIEW INFORMATION
Article has been screened for originality
Externally peer reviewed.
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